Every condition that qualifies for the Texas Compassionate Use Program (TCUP), grouped by the 2017 NASEM consensus report evidence tiers. Cross-linked to clinical condition pages where available. Compiled by the Miracle Leaf® physician network.
Statutory authority: Texas Compassionate Use Program (TCUP). Patient minimum age: No statutory minimum. Out-of-state reciprocity: Not honored.
See the full step-by-step process on the Texas medical marijuana card guide.
Conclusive or substantial evidence
Chronic Pain
Pain persisting beyond expected healing time, lasting months or longer. Cannabis and cannabinoids have substantial evidence for treating chronic pain in adults.
Multiple Sclerosis Spasticity
Patient-reported muscle spasticity in adults with multiple sclerosis. The 2017 NASEM consensus report found substantial evidence that oral cannabinoids improve patient-reported MS spasticity symptoms in adults.
Epilepsy
Neurological disorder characterized by recurrent unprovoked seizures. Cannabidiol (CBD) has strong evidence for reducing seizure frequency in two rare childhood epilepsy syndromes (Dravet syndrome and Lennox-Gastaut syndrome) and is FDA-approved as Epidiolex for those indications.
Seizure Disorders
Neurological conditions involving abnormal electrical activity in the brain that produces seizures. Cannabidiol has strong evidence for reducing seizure frequency in specific syndromes (Dravet, Lennox-Gastaut, and tuberous sclerosis complex) and is FDA-approved as Epidiolex for those indications.
Moderate evidence
Cancer
Group of diseases involving uncontrolled cell growth. Cannabis and cannabinoids have substantial evidence for treating chemotherapy-induced nausea and vomiting (CINV) and moderate evidence for improving sleep disturbance among cancer patients; antitumor effects remain investigational.
Spinal Cord Injury
Damage to the spinal cord resulting in temporary or permanent changes in motor, sensory, or autonomic function. Cannabis has moderate evidence for reducing spasticity and managing neuropathic pain in spinal cord injury patients.
Limited evidence
Post-Traumatic Stress Disorder
A trauma- and stressor-related disorder that follows exposure to a traumatic event. The 2017 NASEM consensus report found limited evidence that nabilone is effective for improving sleep outcomes in PTSD; broader symptom relief evidence remains limited.
Amyotrophic Lateral Sclerosis (ALS)
Progressive neurodegenerative disease affecting motor neurons. Cannabis has limited evidence for managing spasticity, sleep, pain, and appetite loss in ALS patients; no evidence to date demonstrates disease-modifying effects.
Crohn's Disease
Chronic inflammatory bowel disease affecting any portion of the gastrointestinal tract. Cannabis has limited evidence for symptomatic improvement (pain, sleep, appetite) in Crohn's patients but no evidence for inducing or maintaining clinical remission.
Parkinson's Disease
Progressive neurodegenerative disorder primarily affecting movement. Cannabis has limited evidence for symptomatic relief of tremor, sleep disturbance, and pain in Parkinson's patients; no evidence of disease-modifying or neuroprotective effect to date.
Alzheimer's Disease
Progressive neurodegenerative disease and the most common cause of dementia. Cannabis has limited evidence for managing behavioral and psychological symptoms of dementia (agitation, sleep disturbance, appetite loss); no evidence demonstrates disease-modifying effects.
Huntington's Disease
Inherited progressive neurodegenerative disorder causing movement, cognitive, and psychiatric symptoms. Cannabis has limited evidence for managing chorea, sleep, and pain in Huntington's patients; no disease-modifying effect.
Insufficient evidence
Autism Spectrum Disorder
Neurodevelopmental condition characterized by differences in social communication and restricted/repetitive behaviors. Cannabis has insufficient high-quality evidence for treating core autism symptoms; limited evidence exists for managing severe behavioral symptoms in specific subgroups.
Diagnosis documentation
Texas physicians evaluate qualifying patients against the statutory criteria during the visit. Bring documentation of your condition from your treating clinician: a recent office note, hospital discharge summary, specialist letter, or radiology or pathology report works in most cases. Miracle Leaf® staff can confirm whether your records meet the program requirement before you schedule the evaluation.
Frequently asked questions
Is recreational marijuana legal in Texas?
No. Recreational cannabis is illegal statewide. Possession of under 2 oz is a Class B misdemeanor with up to 180 days in jail and a $2,000 fine. Larger amounts scale to felony, with substantial quantities triggering 1st-degree felony penalties of up to life under TX Health & Safety Code §§481.121 and 481.122. Austin, Houston, Dallas, and San Antonio operate municipal cite-and-release programs.
Who qualifies for the Texas Compassionate Use Program?
Texas Health & Safety Code Chapter 487, as expanded by HB 46 of 2025, lists qualifying conditions: epilepsy and seizure disorders, all cancers, autism spectrum disorder, multiple sclerosis, ALS, spasticity, incurable neurodegenerative diseases (Alzheimer's, Parkinson's, Huntington's), PTSD, chronic pain, Crohn's disease, and traumatic brain injury.
What are Texas medical possession limits?
TCUP authorizes physician-prescribed low-THC cannabis capped at 1% THC by weight (raised from 0.5% by HB 1535 in 2021). Approved forms are oils, tinctures, capsules, lozenges, patches, lotions, and vaporization (the latter three authorized by HB 46 in 2025). Smokable flower is not permitted. Patients must purchase from one of three licensed dispensaries.
Can Texas patients grow cannabis at home?
No. Home cultivation is prohibited under TCUP. All medical cannabis must be purchased from a state-licensed dispensary (currently Compassionate Cultivation, Surterra Texas, and Goodblend). Patients pay out of pocket; Texas insurance does not cover TCUP products.
Sources and citations
- Texas Health & Safety Code Chapter 487: Compassionate-Use Program
- NORML: Texas Laws & Penalties
- Wikipedia: Cannabis in Texas (legislative history backlinks)
Last reviewed: 2026-05-17. Evidence tiers reflect the 2017 NASEM consensus report on cannabis and cannabinoids. Not medical advice — consult a licensed clinician.