Pain persisting beyond expected healing time, lasting months or longer. Cannabis and cannabinoids have substantial evidence for treating chronic pain in adults.
What it is
Chronic pain persists beyond the expected period of healing, typically defined as longer than three months.
Cannabis and cannabis-derived therapies
The 2017 NASEM consensus report found conclusive or substantial evidence that cannabis or cannabinoids are effective for chronic pain in adults.
State eligibility for Chronic Pain
| State | Qualifies? | Program |
|---|---|---|
| Florida | Yes | Florida OMMU |
| Georgia | Yes | GMCC Low-THC Registry |
| Texas | Yes | Texas Compassionate Use Program |
If your state lists Chronic Pain as a qualifying condition, a Miracle Leaf® physician can evaluate you for certification.
Frequently asked questions
How strong is the evidence that cannabis helps chronic pain?
The 2017 NASEM report classified the evidence as conclusive or substantial (its highest tier) that cannabis or cannabinoids are effective for chronic pain in adults. Effect sizes in clinical trials are modest, comparable to other adjunct analgesics, and benefits are most consistent for neuropathic pain.
Is cannabis a clinical alternative to opioids?
There is observational evidence that some patients reduce or substitute opioid use after starting cannabis for chronic pain, but the data are mixed and randomized trials are limited. NIH does not currently endorse cannabis as a clinical opioid-replacement therapy.
Which kinds of chronic pain respond best?
Neuropathic pain (including diabetic neuropathy and chemotherapy-induced peripheral neuropathy) has the strongest evidence base. Inflammatory and musculoskeletal pain show inconsistent results across trials. Cancer-associated pain has moderate evidence.
Are there risks for long-term cannabis use for pain?
Yes. Long-term cannabis use is associated with cannabis use disorder (in roughly 9% of adult users; higher in adolescent-onset users), cognitive effects, and respiratory symptoms when smoked. Patients with cardiovascular disease, psychiatric conditions, or who are pregnant should consult their clinician before starting.
Patient guidance from Miracle Leaf®
Cannabis is one of several treatment options patients with chronic pain may consider. Our physicians evaluate each patient against the qualifying-condition criteria of their state program and discuss expected benefits and risks based on current clinical evidence. We coordinate with your other treating clinicians where appropriate.
Miracle Leaf® brand products including CBD, Delta-8, and low-THC formulations are available for in-store pickup and nationwide shipping through Miracle Leaf® Store.
Sources and citations
- NASEM: The Health Effects of Cannabis and Cannabinoids
“Conclusive or substantial evidence that cannabis or cannabinoids are effective for chronic pain in adults.” - NIH NCCIH: Cannabis and Cannabinoids
Last reviewed: 2026-05-17. This page summarizes current peer-reviewed evidence and federal guidance, and is updated whenever the source documents materially change. Not medical advice — consult a licensed clinician before starting or modifying any treatment.